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Holoprosencephaly, microcephaly, facial abnormalities, cardiac abnormalities, enlarged and echogenic kidneys, exomphalos and post axial polydactyly. The amplification inhibits the expression of gene FMR The venue of FISH technique and other means to identify abnormal chromosomal complements, and the PCR polymerase chain reaction for molecular analysis have recently convince researchers not to abandon this avenue which could be a great asset to the prenatal diagnosis of genetic disease. In our Prenatal Diagnosis Unit, 1, CV samples were obtained by transcervical sampling before evacuation. The rate of chromosome abnormalities in the AMA group was significantly higher

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For security reasons this invasive technique is not a routine procedure and is rarely utilized except in development programs.

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There were 26 cases with double trisomy, representing 1. However, our data are in contrast to the findings of Eiben et al. Claudia Guaraldi. We knew that if the NIPT result had shown a high likelihood for a chromosomal condition, it would have allowed us more time to prepare for our child's unique needs and the road ahead. Chromosomal instability I- 5. Cardiac ultrasonography II- 3.

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